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Lu AF21934
CAS No. 1445605-23-1
Lu AF21934 ( Lu AF21934; Lu AF-21934; Lu AF 21934 )
产品货号. M17302 CAS No. 1445605-23-1
Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥365 | 有现货 |
|
| 5MG | ￥583 | 有现货 |
|
| 10MG | ￥1045 | 有现货 |
|
| 25MG | ￥2292 | 有现货 |
|
| 50MG | ￥3734 | 有现货 |
|
| 100MG | ￥5484 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Lu AF21934
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
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产品描述Lu AF21934 is a positive allosteric modulator of mGlu4 receptors. Lu AF21934 reduces the harmaline-induced hyperactivity but not tremor in rats. The actions of Lu AF21934 are 5-HT1A receptor-dependent. Activation of the mGlu4 receptor may be a promising mechanism for the development of novel antipsychotic drugs, efficacious toward positive, negative, and cognitive symptoms.
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同义词Lu AF21934; Lu AF-21934; Lu AF 21934
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通路Angiogenesis
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靶点ALK
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受体mGluR4
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研究领域——
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适应症——
化学信息
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CAS Number1445605-23-1
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分子量315.2
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分子式C14H16Cl12N2O2
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纯度98%
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溶解度DMSO : ≥ 80 mg/mL. 253.81 mM
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SMILESC1CC[C@@H]([C@@H](C1)C(=O)N)C(=O)Nc1cc(c(cc1)Cl)Cl
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化学全称(1S,2R)-N1-(3,4-Dichlorophenyl)cyclohexane-1,2-dicarboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sawińska A,et al. Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu receptor. Neuropharmacology. 2013 Mar;66:225-35.
产品手册
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